Better Therapeutic Outcomes for Atopic Dermatitis Patients Guided by Gene Expression Profiling

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Marcia J. Glenn, MD
Amanda Caldwell, FNP-C
Valerie Cooper, PA-C, MPAS
Vivian Hunt, APRN, DCNP
Chioma Okpala, BSc.

Keywords

Atopic dermatitis, biologic therapies, JAK inhibitor, 487-GEP, gene expression profiling

References

1. Eczema facts and statistics. National Eczema Association. Accessed November 15, 2025.

2. Castle Biosciences reports preliminary data from atopic dermatitis test study. Medical Device Network. December 2024.

3. CADTH Cost-Comparison Table for Moderate-to-Severe Atopic Dermatitis. NCBI Bookshelf. Accessed November 15, 2025.

4. Mehrmal S, Tan MG, Arron ST, et al. Gene Expression Profiling (GEP) in Dermatology, Part 1: Introduction, Development, Benefits, Limitations, and Future Directions. Journal of the American Academy of Dermatology. 2025.

5. Farberg A, Hebebrand M. Explains Gene Profiling in Atopic Dermatitis. Dermatology Times. October 2025.

6. Silverberg JI, Eichenfield LF, Armstrong A, et al. The 487-Gene Expression Profile Test Guides Systemic Therapy Selection to Improve Outcomes for Patients with Atopic Dermatitis: Results from a Prospective, Multi-Center Trial. SKIN The Journal of Cutaneous Medicine. 2025;9(6):s621.

7. 487-GEP Test Identifies Optimal Systemic Therapy for AD. Practical Dermatology. October 2025.

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