Cutaneous Angioneurofibroma: A Vascularized Histopathologic Variant of Neurofibroma
Main Article Content
Keywords
angioneurofibroma, neurofibroma
Abstract
Angioneurofibroma is a rare histopathological variant of cutaneous neurofibroma, characterized by a more densely vascularized stroma when compared to classic neurofibroma. Here we describe a case of this entity, which presented as a tender penile plaque in a young man, and discuss the clinicopathologic differential. The unique histologic findings in this case supports the recognition of angioneurofibroma as a distinct subtype of neurofibroma, and dermatologists should be aware of this rare variant.
References
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2. Megahed M. Histopathological variants of neurofibroma. A study of 114 lesions. Am J Dermatopathol. Oct 1994;16(5):486-95. doi:10.1097/00000372-199410000-00003
3. Waggener JD. Ultrastructure of benign peripheral nerve sheath tumors. Cancer. May 1966;19(5):699-709. doi:10.1002/1097-0142(196605)19:5<699::aid-cncr2820190516>3.0.co;2-h
4. Tepavicharova P. Rare location of Recklinghausen's disease (case report). Acta Chir Plast. 1989;31(3):129-33.
5. Fleming GW. A Case of Multiple Neurofibromata Associated with a True Angioneurofibroma of the Acoustic Nerve, Jacksonian Epilepsy and Osteoporosis. J Neurol Psychopathol. Aug 1925;6(22):104-13. doi:10.1136/jnnp.s1-6.22.104
6. Ymele FF, Bechem E, Njotang PN, et al. A rare tumour of the vulva: a case report of a vulva angioneurofibroma hamartoma in a Cameroonian woman. Pan Afr Med J. 2013;15:115. doi:10.11604/pamj.2013.15.115.2597
7. Calonje E, Brenn T, Lazar A, Billings SD. McKee's pathology of the skin with clinical correlations. Fifth edition. ed. Pathology of the skin with clinical correlations. Elsevier Limited; 2020.
8. Sutton BJ, Laudadio J. Aggressive angiomyxoma. Arch Pathol Lab Med. Feb 2012;136(2):217-21. doi:10.5858/arpa.2011-0056-RS