Palmoplantar Psoriasis Treatment with Topical Roflumilast 0.3%
Main Article Content
Keywords
Palmoplantar Psoriasis, Topical Roflumilast treatment for Palmoplantar Psoriasis, Topical Roflumilast
Abstract
Palmoplantar psoriasis is a manifestation of psoriasis that includes pustules, scales, and erythematous hyperkeratotic plaques on the palms of the hands and the soles of the feet. Despite being limited to these regions, palmoplantar psoriasis is difficult to treat and imposes a greater level of quality-of-life burden compared to plaque psoriasis. We describe a case of palmoplantar psoriasis refractory topical corticosteroid and dupilumab that was successfully treated with topical roflumilast 0.3% once daily.
References
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2. Chung J, Callis Duffin K, Takeshita J, Shin DB, Krueger GG, Robertson AD, Troxel AB, Van Voorhees AS, Edson-Heredia E, Gelfand JM. Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis. J Am Acad Dermatol. 2014 Oct;71(4):623-32. doi: 10.1016/j.jaad.2014.04.063. Epub 2014 Jun 2. PMID: 24894455; PMCID: PMC4165651.
3. Farley E., Masrour S., McKey J., Menter A. Palmoplantar psoriasis: A phenotypical and clinical review with introduction of a new quality-of-life assessment tool. J. Am. Acad. Dermatol. 2009;60:1024–1031. doi: 10.1016/j.jaad.2008.11.910.
4. Pettey A.A., Balkrishnan R., Rapp S.R., Fleischer A.B., Feldman S.R. Patients with palmoplantar psoriasis have more physical disability and discomfort than patients with other forms of psoriasis: Implications for clinical practice. J. Am. Acad. Dermatol. 2003;49:271–275. doi: 10.1067/S0190-9622(03)01479-8.
5. Hoegler KM, John AM, Handler MZ, Schwartz RA. Generalized pustular psoriasis: a review and update on treatment. J Eur Acad Dermatol Venereol. 2018 Oct;32(10):1645-1651. doi: 10.1111/jdv.14949. Epub 2018 Apr 11. PMID: 29573491.
6. Successful treatment of palmoplantar psoriasis with chemical peeling and gentian violet Bubley, Jeffrey A. et al. JAAD Case Reports, Volume 17, 28 – 30.