Improvement of Suspected Linear Morphea seen with Topical Ruxolitinib

Main Article Content

Shivkar Amara
Miyahra Lopez
Mark Lebwohl

Keywords

Linear morphea, ruxolitinib cream

Abstract

Linear morphea is an autoimmune skin condition characterized by localized sclerosis and discoloration. Current standard of care includes topical and intralesional steroids, phototherapy, and immunosuppressive agents; however, no gold-standard treatment exists. We present a 34-year-old female who presented with a hypopigmented and indurated plaque in an en coup de sabre configuration on her forehead, suspicious of linear morphea, that improved significantly in thickness and hypopigmentation after eight weeks of 1.5% ruxolitinib cream.

References

1. Janus kinase inhibitors for treatment of morphea and systemic sclerosis: A literature review - McGaugh - 2022 - Dermatologic Therapy - Wiley Online Library. Accessed August 13, 2023. https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.15437

2. Diagnostic criteria, severity classification and guidelines of localized scleroderma - Asano - 2018 - The Journal of Dermatology - Wiley Online Library. Accessed August 13, 2023. https://onlinelibrary.wiley.com/doi/full/10.1111/1346-8138.14161

3. Szczęch J, Samotij D, Jaworecka K, Tobiasz A, Reich A. Quality of Life in Patients with Morphea: A Cross-Sectional Study and a Review of the Current Literature. Biomed Res Int. 2020;2020:9186274. doi:10.1155/2020/9186274

4. Penmetsa GK, Sapra A. Morphea. In: StatPearls. StatPearls Publishing; 2023. Accessed August 13, 2023. http://www.ncbi.nlm.nih.gov/books/NBK559010/

5. Ulc E, Rudnicka L, Waśkiel-Burnat A, Warszawik-Hendzel O, Niemczyk A, Olszewska M. Therapeutic and Reconstructive Management Options in Scleroderma (Morphea) en Coup de Sabre in Children and Adults. A Systematic Literature Review. J Clin Med. 2021;10(19):4517. doi:10.3390/jcm10194517

6. Wenzel D, Haddadi NS, Afshari K, Richmond JM, Rashighi M. Upcoming treatments for morphea. Immunity, Inflammation and Disease. 2021;9(4):1101-1145. doi:10.1002/iid3.475

7. Pedroza M, To S, Assassi S, Wu M, Tweardy D, Agarwal SK. Role of STAT3 in skin fibrosis and transforming growth factor beta signalling. Rheumatology (Oxford). 2018;57(10):1838-1850. doi:10.1093/rheumatology/kex347

8. Sheikh A, Rafique W, Owais R, Malik F, Ali E. FDA approves Ruxolitinib (Opzelura) for Vitiligo Therapy: A breakthrough in the field of dermatology. Ann Med Surg (Lond). 2022;81:104499. doi:10.1016/j.amsu.2022.104499

9. Papara C, De Luca DA, Bieber K, Vorobyev A, Ludwig RJ. Morphea: The 2023 update. Front Med (Lausanne). 2023;10:1108623. doi:10.3389/fmed.2023.1108623

10. Mertens JS, Seyger MMB, Thurlings RM, Radstake TRDJ, de Jong EMGJ. Morphea and Eosinophilic Fasciitis: An Update. Am J Clin Dermatol. 2017;18(4):491-512. doi:10.1007/s40257-017-0269-x

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>