Effects of Mineral and Almond Oil Administration on Transepidermal Water Loss and Skin Acidity in Chronic Renal Failure Patients Undergoing Hemodialysis
Main Article Content
Keywords
almond oil, chronic renal failure, hemodialysis, mineral oil, skin acidity, transepidermal water loss
Abstract
Introduction: Patients undergoing hemodialysis experience decreased moisture content in the dermis due to fluid transfer during the dialysis process, causing xerosis, pruritus, and damage to the skin barrier. Almond oil and mineral oil are well-known moisturizers used in skin care products.
Objectives: To compare the effect of almond oil with mineral oil on transepidermal water loss (TEWL) and skin acidity in hemodialyzed chronic renal failure (CRF) patients.
Methods: An experimental study was conducted on patients with chronic renal failure (CRF) undergoing hemodialysis at Dr. Moewardi Hospital in Indonesia. The study involved applying mineral and almond oils twice daily on the right and left forearms for four weeks. We measured TEWL and pH levels before and after the treatment.
Results: There is a significant difference in TEWL between before and after mineral oil application (p=0.036), but not in the almond oil arm (p=0.394). Subsequently, the change of TEWL value significantly differed between mineral oil and almond oil (p=0.043). However, the effects of mineral oil and almond oil on pH were insignificant (p=0.574 and 0.268, respectively).
Conclusion: After undergoing hemodialysis, CRF patients experienced a statistically significant reduction in transepidermal water loss (TEWL) when using mineral oil compared to both baseline and almond oil.
References
2. Green M, Kashetsky N, Feschuk A, Maibach HI. Transepidermal water loss (TEWL): Environment and pollution—A systematic review. Skin health and disease. 2022;2(2):e104.
3. Nareswari A, Oktriana P, Bhadra P, Widhiati S, et al. Neonatal transepidermal water loss difference based on gestational age, gender, birth weight, mode of delivery, and family history of atopy. Media Dermato-Venereologica Indonesiana. 2020;47(1):9–15.
4. Lukić M, Pantelić I, Savić SD. Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products. Cosmetics. 2021;8(3):69.
5. Kuo SH, Shen CJ, Shen CF, Cheng CM. Role of pH value in clinically relevant diagnosis. Diagnostics. 2020;10(2):107.
6. Agarwal P, Garg V, Karagaiah P, Szepietowski JC, Grabbe S, Goldust M. Chronic kidney disease-associated pruritus. Toxins (Basel). 2021;13(8):527.
7. Kurniawan M, Regina R. The correlation between pruritus and xerosis with the quality of life of patients undergoing hemodialysis in Atma Jaya Hospital. Journal of Pakistan Association of Dermatologists. 2022;32(2):288–92.
8. Chang PC, Liao IC. Hydration, barrier of skin and uremic pruritus in patients undergoing hemodialysis: A pilot investigation. Nephrol Ther. 2022;18(6):498–505.
9. Lopez-Ojeda W, Pandey A, Alhajj M, Oakley AM. Anatomy, skin (integument). In: StatPearls [Internet]. StatPearls Publishing; 2022.
10. Sandig S, Yousef H, Diercks T, Radsak M, et al. The Skin Barrier—structure and function of the Stratum corneum. Int J Mol Sci. 2021;22(2):3035–9.
11. Alexander H, Brown S, Danby S, Flohr C. Research techniques made simple: transepidermal water loss measurement as a research tool. Journal of Investigative Dermatology. 2018;138(11):2295–300.
12. Hiramoto K, Goto K, Tanaka S, Horikawa T, Ooi K. Skin, liver, and kidney interactions contribute to skin dryness in aging KK-Ay/Tajcl mice. Biomedicines. 2022;10(10):2648.
13. Mawazi SM, Ann J, Othman N, Khan J, Alolayan SO, Al thagfan SS, et al. A review of moisturizers; history, preparation, characterization and applications. Cosmetics. 2022;9(3):61.
14. Stamatas GN. Mineral oil in skin care: safety profile. Lipids and skin health. 2015;291–9.
15. Sousa GD, de Souza Dantas IMF, De Santana DP, Leal LB. New oils for cosmetic o/w emulsions: In vitro/in vivo evaluation. Cosmetics. 2018;5(1):6.
16. Rawlings A V, Lombard KJ. A review on the extensive skin benefits of mineral oil. Int J Cosmet Sci. 2012;34(6):511–8.
17. Blaak J, Staib P. An updated review on efficacy and benefits of sweet almond, evening primrose and jojoba oils in skin care applications. Int J Cosmet Sci. 2022;44(1):1–9.
18. Santoro F, Teissedre S. A novel night moisturizer enhances cutaneous barrier function in dry skin and improves dermatological outcomes in rosacea-prone skin. J Clin Aesthet Dermatol. 2018;11(12):11.
19. de las Alas JMG, Carpio VM, Lim MEL, Frez MLF. Randomized controlled trial on the efficacy and safety of virgin coconut oil compared to mineral oil in the treatment of uremic xerosis. Acta Med Philipp. 2014;48(4).
20. Singh VS, Vinayadev V. Effectiveness of baby oil therapy for uremic pruritus in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2021;32(1):163–9.