Treatment of Generalized Pustular Psoriasis with Bimekizumab

Main Article Content

Mimi Chung
Boni E Elewski

Keywords

generalized pustular psoriasis, bimekizumab, infliximab, plaque psoriasis, psoriatic arthritis

Abstract

Generalized pustular psoriasis (GPP) is a rare but serious subtype of pustular psoriasis. In the United States, the IL-36 inhibitor spesolimab is the only medication currently approved for GPP. We describe the longitudinal treatment of a patient with concomitant GPP, plaque psoriasis, and psoriatic arthritis. After almost a decade of recalcitrant disease and difficulty managing cardiovascular concerns, the patient was successfully treated with bimekizumab, a novel biologic targeting IL-17A/F. To our knowledge, this represents the first case of concomitant GPP and plaque psoriasis treated with this immunomodulator, offering additional treatment options for patients with this challenging disease.

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