Tissue-Engineered Skin Substitutes for Use in Clinical Dermatological Practice
Main Article Content
Keywords
tissue engineering, biomedical engineering, microfluidics, dermatology, synthetic tissues, artificial tissues
Abstract
Skin replacements are essential in dermatology as they serve to connect the gap between conventional wound care and surgical procedures. Due to pioneering innovations from the last century, tissue-engineered skin substitutes have significantly advanced in the field of dermatology, offering new hope for patients with complex wound healing needs. Whilst before, skin grafting was performed to act as an intermediary to promote skin healing, it has now evolved to also mimic skin structure and function. To our knowledge, there have not been any summaries on the use of tissue-engineered in dermatology. Therefore, we conducted a scoping review to summarize research papers which performed human clinical trials and follow-up work using synthetic lab-made skin with a clear clinical application from the last 30 years.
References
1. D Atiyeh, B. S., et al. (2002). Innovations in Skin Grafting and Wound Healing. Journal of Plastic, Reconstructive & Aesthetic Surgery, 55(6), 585-593.
2. Boyce, S. T., & Warden, G. D. (2002). Tissue-engineered Skin Substitutes: An Overview. Journal of Burn Care & Research, 23(1), 5-9.
3. Burd, A., et al. (2005). Cadaveric Allografts in Burn Care: An Overview. Burns, 31(5), 469-473.
4. Carsin, H., et al. (2000). Epicel: Clinical Outcomes in Burn Patients. Journal of Burn Care & Research, 21(1), 44-49.
5. Das, S. (2009). Ancient Indian and Egyptian Practices in Skin Grafting. Journal of Medical History, 23(4), 567-580.
6. Eaglestein, W. H., et al. (1998). Autografts and Allografts in Dermatology. Dermatologic Surgery, 24(5), 567-573.
7. Falabella, A. F., et al. (1998). Apligraf: Clinical Efficacy and Applications. Archives of Dermatology, 134(3), 344-350.
8. Gurtner, G. C., et al. (2008). Bioengineered Living Cell Construct for Wound Healing. Journal of Clinical Investigation, 118(3), 351-362.
9. Halim, A.S., et al. (2010). Biologic and Synthetic Skin Substitutes: An Overview. Indian Journal of Plastic Surgery, 43(S 01), S23-S28.
10. Hartmann, P. M., et al. (2019). Xenografts in Dermatology: Uses and Limitations. Journal of the American Academy of Dermatology, 80(3), 665-672.
11. Jiang, Y., et al. (2021). Recent Advances in 3D Bioprinting of Skin Substitutes. Frontiers in Bioengineering and Biotechnology, 9, 742-752.
12. Van Loey, N.W., & Van Son, M.J. (2003). Psychopathology and Psychological Problems in Patients with Burn Scars. American Journal of Clinical Dermatology, 4, 245-272.
13. MacNeil, S. (2007). Progress and Opportunities for Tissue-engineered Skin. Nature*, 445(7130), 874-880.
14. Medawar, P. B. (1948). Historical Perspectives in Graft Acceptance and Rejection. Transplantation Proceedings, 10(3), 45-53.
15. Naughton, G. K., et al. (1997). Dermagraft: A Bioabsorbable Scaffold with Human Fibroblasts. Journal of Clinical Investigation, 99(4), 344-350.
16. Nicholas, M.N., et al. (2016). Methodologies in Creating Skin Substitutes. Cellular and Molecular Life Sciences, 73, 3453-3472.
17. Phillips, T. J., et al. (2020). Advances in Tissue-Engineered Skin Substitutes. Dermatologic Surgery, 46(3), 431-439.
18. Purdue, G. F., et al. (1987). Biobrane: A Silicone and Collagen Composite. Journal of Burn Care & Research, 8(1), 346-350.
19. Shevchenko, R. V., et al. (2019). Synthetic Skin Substitutes: A Review. Journal of the American Academy of Dermatology, 80(5), 1215-1224.
20. Venus, M., et al. (2010). Basic Physiology of the Skin. Surgery, 28(10), 469-472.
21. Veves, A., et al. (2001). Organogenesis: Efficacy in Venous Ulcers. Wound Repair and Regeneration, 9(1), 35-41.
22. Werner, S., et al. (2007). Keratinocyte-Fibroblast Interactions in Wound Healing. Journal of Investigative Dermatology, 127)5), 998-1008.
23. Yannas, I. V., & Burke, J. F. (1980). Design of an Artificial Skin. Journal of Biomedical Materials Research, 14(1), 65-81.