Evaluating the Role of Age in Healing Times for Radiation Dermatitis

Main Article Content

Aneri Patel
UC Davis School of Medicine

Keywords

radiation dermatitis, radiation therapy, wound healing

Abstract

Introduction: While previous research has focused on RD management, little is known about the relationship between age and healing times.


Methods: Adult patients with cancer and RD were identified via ICD-10 codes from the Patient Research Data Registry. Univariable analyses using Kaplan–Meier estimators with log-rank tests assessed survival outcomes.


Results: Younger patients had shorter times from the end of RT to resolution (p = 0.018) and from diagnosis to resolution (p = 0.02), suggesting that age influences recovery post-radiation injury.


Discussion: Older patients may benefit from tailored interventions, such as enhanced wound care protocols or skin barrier therapies. Incorporating age into RD management algorithms could optimize treatment plans and help mitigate delayed healing.

References

1. Singh, M., Alavi, A., Wong, R. et al. Radiodermatitis: A Review of Our Current Understanding. Am J Clin Dermatol 17, 277–292 (2016). https://doi.org/10.1007/s40257-016-0186-4

2. Xie, Y., Hu, T., Chen, R. et al. Predicting acute radiation dermatitis in breast cancer: a prospective cohort study. BMC Cancer, 537 (2023). https://doi.org/10.1186/s12885-023-10821-6

3. Quan, T. (Ed.). (2016). Molecular Mechanisms of Skin Aging and Age-Related Diseases (1st ed.). CRC Press. https://doi.org/10.1201/b21370

4. Guo, S., & DiPietro, L.A. (2010). Factors Affecting Wound Healing. Journal of Dental Research, 89(3), 219–229. https://doi.org/10.1177/0022034509359125

5. Leventhal J, Young MR. Radiation Dermatitis: Recognition, Prevention, and Management. Oncology (Williston Park). 2017 Dec 15;31(12):885-7, 894-9. PMID: 29297172.

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Published
2025-10-07
DOI: https://doi.org/10.25251/skin.9.3.6

Article Details

How to Cite
1.
Evaluating the Role of Age in Healing Times for Radiation Dermatitis. J of Skin. 2025;9(3):2322-2325. doi:10.25251/skin.9.3.6
Issue
Vol. 9 No. 3 (2025): May 2025 Issue
Section
Research Letters
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