Complete Resolution of Localized Granuloma Annulare with Oral Abrocitinib
Main Article Content
Keywords
granuloma annulare, abrocitinib, jak inhibitor
Abstract
Granuloma annulare (GA) is an inflammatory granulomatous skin reaction with varied clinical presentations that preferentially affects women. Currently, treatments for granuloma annulare include topical or intralesional corticosteroids for localized disease and antibiotics, hydroxychloroquine, methotrexate, TNF-a inhibitors, pentoxifylline, and phototherapy for widespread disease. A treatment challenge to this approach is the lack of effective options for localized disease. We describe complete resolution of localized granuloma annulare with oral abrocitinib.
References
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2. Min MS, Wu J, He H, et al. Granuloma annulare skin profile shows activation of T-helper cell type 1, T-helper cell type 2, and Janus kinase pathways. J Am Acad Dermatol. 2020;83(1):63-70. doi:10.1016/j.jaad.2019.12.028
3. Joshi TP, Duvic M. Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options. Am J Clin Dermatol. 2022;23(1):37-50. doi:10.1007/s40257-021-00636-1
4. Wang A, Rahman NT, McGeary MK, et al. Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib. Journal of Allergy and Clinical Immunology. 2021;147(5):1795-1809. doi:10.1016/j.jaci.2020.10.012
5. Damsky W, Thakral D, McGeary MK, Leventhal J, Galan A, King B. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. Journal of the American Academy of Dermatology. 2020;82(3):612-621. doi:10.1016/j.jaad.2019.05.098
6. Perche PO, Cook MK, Feldman SR. Abrocitinib: A New FDA-Approved Drug for Moderate-to-Severe Atopic Dermatitis. Ann Pharmacother. 2023;57(1):86-98. doi:10.1177/10600280221096713
7. Damsky W. JAK1 Inhibition in Granuloma Annulare: An Opportunity for Pathogenesis Directed Therapy. clinicaltrials.gov; 2024. Accessed February 25, 2025. https://clinicaltrials.gov/study/NCT05650736
8. Liu W, Chen W, Tian X, et al. Oral abrocitinib in the treatment of granuloma annulare: a case report. Journal of Dermatological Treatment. 2024;35(1):2313090. doi:10.1080/09546634.2024.2313090
