EFFISAYIL OBSERVE: A real-world descriptive study of patients with generalized pustular psoriasis (GPP) in the USA

Main Article Content

Mark G. Lebwohl
Raj Chovatiya
Laura K. Ferris
Kori Stetter
Becca S. Feldman
Brent E. Mancha
Ikenna Unigwe
Nichiren Pillai
Bhargav Lakshminarasimhan
Jason Guercio
Alice B. Gottlieb

Keywords

Generalized Pustular Psoriasis, Non-interventional, Observational, Real-world study

Abstract

• GPP is a chronic, neutrophilic inflammatory disease, driven by dysregulation of theinterleukin-36 pathway, and associated with systemic symptoms and high disease burden.


• The estimated prevalence of GPP in the USA is 0.9 per 10,000 individuals.       


• Given the rarity of GPP, real-world data describing treatment patterns and HCRU associated with the disease are limited.


• To address this knowledge gap, the EFFISAYIL OBSERVE study collected real-world data from the medical records of a representative cohort of patients with GPP in the USA.

References

1. Kole LCS, et al. Dermatol Ther (Heidelb) 2025;doi:10.1007/s13555-025-01483-2.

2. Armstrong AW, et al. J Am Acad Dermatol 2024;90:727–30.

3. Puig L, et al. J Eur Acad Dermatol Venereol 2023;37(4):737–52.

4. Noe MH, et al. J Psoriasis Psoriatic Arthritis 2025; 10(2):51–7.

5. Boehringer Ingelheim. Press release. https://www.boehringer-ingelheim.com/humanhealth/skin-and-inflammatory-diseases/gpp/us-fda-approves-first-treatment-generalizedpustular-psoriasis-flares-adults. Accessed September 9, 2025.

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