Cost-Per-Responder Analysis of Delgocitinib Topical Cream Versus Dupilumab Subcutaneous Injection for Moderate to Severe Atopic Hand Eczema in the United States

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Sanjeev Balu
Amanda Falah Rasmussen
Aseel Bin Sawad
Eydna Didriksen Apol
Pravin Kamble
Douglas Maslin
Anne Sofie Loftager

Keywords

delgocitinib, atopic hand eczema, dupilumab

References

1. Thyssen JP et al. 2022. Guidelines for diagnosis, prevention, and treatment of hand eczema. Contact Dermatitis;

2. Quaade AS et al. 2021. Prevalence, incidence, and severity of hand eczema in the general population – A systematic review and meta-analysis. Contact Dermatitis;

3. Weisshaar E. 2024. Chronic Hand Eczema. Am J Clin Dermatol;

4. Cazzaniga et al. 2016. Medical, psychological and socio-economic implications of chronic hand eczema: a cross-sectional study. J Eur Acad Dermatol Venereol;

5. Van Gils RF et al. 2009. Integrated, multidisciplinary care for hand eczema: design of a randomized controlled trial and cost-effectiveness study. BMC Public Health;

6. FDA. 2025. Prescribing information: Anzupgo (delgocitinib);

7. Bissonnette et al. 2024. Efficacy and safety of delgocitinib cream in adults with moderate to severe chronic hand eczema (DELTA 1 and DELTA 2): results from multicentre, randomised, controlled, double-blind, phase 3 trials. Lancet;

8. FDA. 2022. Prescribing information: Dupixent (dupilumab);

9. LEO Pharma. 2024. MAIC of delgocitinib (DELTA 1 & 2) vs. dupilumab (LIBERTY-AD-HAFT) (only in AD subtype of CHE) [data on file];

10. Cohen et al. 2024 Matching-adjusted indirect comparison of the efficacy of delgocitinib and dupilumab in the treatment of moderate to severe atopic hand eczema. EADV 2024. Oral presentation;

11. Sanders et al. 2016. Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses: Second Panel on Cost-Effectiveness in Health and Medicine. JAMA;

12. Borg et al. 2024. The management of Chronic Hand Eczema: A retrospective patient record review. Contact Dermatitis;

13. LEO Pharma. 2024. Clinical trial report: Openlabel Multi-site Extension Trial in Subjects Who Completed the DELTA 1 or DELTA 2 Trials (DELTA 3) [data on file];

14. NAVLIN by EVERSANA. 2025. Pricing database, Anzupgo, WAC;

15. NAVLIN by EVERSANA. 2025. Pricing database, Dupixent, WAC;

16. Centers for Medicare and Medicaid Services. 2024. Physician Fee Sched

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