61-Year-Old White Female with a Non-Healing Ulcerated Ankle Mass
Main Article Content
Keywords
Merkel Cell, Ankle Mass, Avelumab, carcinoma
Abstract
Merkel cell carcinoma is a rare cutaneous carcinoma from the tactile Merkel cells. With fewer than half the patients surviving more than one year and fewer than 20% surviving beyond five years. These tumors are rarely suspected until the biopsy results return. Polyoma virus is associated with up to 80% of the tumors. 53% present on the head and neck and 35% present on the extremities while larger lesions are exceedingly rare in either location. Recently, A newly approved drug, Avelumab, has shown tumor response in patients with some patients experiencing complete remission.
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3. Goessling, W, Mckee P, Mayer R. Merkel cell carcinoma. J Clin Oncol. 2002; 20:588 – 598.
4. Oram C , Bartus C S, Purcell S. Merkel cell carcinoma: A review. Cutis. 2016 Volume 97, 4 to 90 – 295
5. Wang T, Byrne, P, Et al, Semin Cutan Med Surg. 2011 Mar:30 (1) 48-56
6. Lemos B, Storer B, Lyer J, et al. Pathologic nodal evaluation approves prognostic accuracy and Merkel cell carcinoma; J Amer Acad Derm. 2010; 63(5): 751 – 761.
7. Bobos M, Hytiroglou P, Kostopoulos I, et al. immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Dermatopathol. 2006; 28:99 – 104.
8. Pearson, J , Meyers, A Skin cancer – Merkel cell carcinoma, Medscape updated March 27, 2017