A Rare Case of Angiolymphoid Hyperplasia without Eosinophils, with Review of the Literature
Main Article Content
Keywords
angiolymphoid hyperplasia with eosinophils, ALHE, epithelioid hemangioma, vascular proliferation
Abstract
The epithelioid hemangioma, more commonly termed angiolymphoid hyperplasia with eosinophils, is a pathologic vascular proliferation characterized by a distinctive eosinophil-rich mixed inflammatory infiltrate. A nonspecific accompanying infiltrate has only rarely been reported, and may confound the diagnosis of this benign process with malignant mimics. We present such a case of angiolymphoid hyperplasia without eosinophils, and consider its diagnosis and pathogenesis within the spectrum of related entities.
References
2. Burrall BA, Barr RJ, King DF. Cutaneous histiocytoid hemangioma. Arch Dermatol. 1982;118:166-70. PMID: 7065665.
3. Guo R, Gavino ACP. Angiolymphoid hyperplasia with eosinophilia. Arch Pathol Lab Med. 2015;139:683-86. doi: 10.5858/arpa.2013-0334-RS.
4. Rosai J, Gold J, Landy R. The histiocytoid hemangiomas. A unifying concept embracing several previously described entities of skin, soft tissue, large vessels, bone, and heart. Hum Pathol. 1979;10:707-30.
5. Buder K, Ruppert S, Trautmann A, et al. Angiolymphoid hyperplasia with eosinophilia and Kimura’s disease – a clinical and histopathological comparison. J Dtsch Dermatol Ges. 2014;12:224-8. doi: 10.1111/ddg.12257_suppl.
6. Fernández-Figueras M-T, Puig L, Armengol M-P, et al. Cutaneous angiolymphoid hyperplasia with high endothelial venules is characterized by endothelial expression of cutaneous lymphocyte antigen. Hum Pathol. 2001;32(2):227-29. doi: 10.1053/hupa.2001.22010.
7. Dokania V, Patil D, Agarwal K, et al. Kimura's disease without peripheral eosinophilia: An unusual and challenging case simulating venous malformation on imaging studies-Case report and review of literature. J Clin Diagn Res. 2017;11:ME01-ME04. doi: 10.7860/JCDR/2017/28603.10063.
8. Su H-H, Shan S-J, Elston DM, et al. Congenital Blaschkoid angiolymphoid hyperplasia with eosinophilia of the anogenital region. Am J Dermatopathol. 2016;38:305-6. doi: 10.1097/DAD.0000000000000542.
9. Grimwood R, Swinehart JM, Aeling JL. Angiolymphoid hyperplasia with eosinophilia. Arch Dermatol. 1979;115:205-7.
10. Okman JS, Bhatti TR, Jackson OA, et al. Angiolymphoid hyperplasia with eosinophilia: a previously unreported complication of ear piercing. Pediatr Dermatol. 2014;31:738-41. doi: 10.1111/pde.12410.
11. Tokat F, Lehman JS, Sezer E, et al. Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia. Dermatol Pract Concept. 2018;8:28-32. doi: 10.5826/dpc.0801a06.
12. Adler BL, Krausz AE, Minuti A, et al. Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): A systematic review. J Am Acad Dermatol. 2016;74:506-12.e11. doi: 10.1016/j.jaad.2015.10.011.