The Role of Kappa- and Mu-Opioid Receptors in Pruritus

Brian Kim; Thomas Sciascia; Gil Yosipovitch

doi:10.25251/skin.5.supp.31

Brian Kim

Washington University, St. Louis, MO

Thomas Sciascia

Trevi Therapeutics, New Haven, CT

Gil Yosipovitch

University of Miami, Miami, FL

Keywords

Pruritus, Mu-Opioid Receptor, Kappa-Opioid Receptor

Abstract

Abstract not available.

References

1. Dong X, Dong X. Neuron. 2018;98(3):482-94.

2. Acton D, et al. Cell Reports. 2019;28(3):625-39.e6.

3. Ständer S, et al. Acta Derm Venereol. 2007;87(4):291-4.

4. Dhand A, Aminoff MJ. Brain. 2014;137(Pt 2):313-22.

5. Yosipovitch G, Bernhard JD. N Engl J Med. 2013;368(17):1625-34.

6. Fowler E, Yosipovitch G. Ann Allergy Asthma Immunol. 2019;123(2):158-65.

7. Kardon AP, et al. Neuron. 2014;82(3):573-86.

8. Snyder LM, et al. Neuron. 2018;99(6):1274-88.e6.

9. Paul B-QL, et al. J Am Acad Dermatol. 2004;50(3 suppl):P29.

10. Yosipovitch G, et al. Lancet. 2003;361(9358):690-4.

11. Phan NQ, et al. Acta Derm Venereol. 2012;92(5):555-60.

12. Peng J, et al. Drug Alcohol Depend. 2012;124(3):223-8.

13. Potenzieri C, Undem BJ. Clin Exp Allergy. 2012;42(1):8-19.

14. Chen XJ, Sun YG. Nature Communications. 2020;11(1):3052.

15. Fowler E, Yosipovitch G. Acta Derm Venereol. 2020;100(2):adv00027.

16. Pathan H, Williams J. Br J Pain. 2012;6(1):11-6.

17. Tubog TD, et al. J Perianesth Nurs. 2019;34(3):491-501.e8.

18. Inan S, et al. Eur J Pharmacol. 2019;864:172702.

19. Sehgal N, et al. Pain Physician. 2011;14(3): 249-58.

20. Valentino RJ, Volkow ND. Neuropsychopharmacology. 2018;43(13):2514-20.

21. Pereira PJ, Lerner EA. Neuron. 2014;82(3):503-5.

22. Ross SE, et al. Neuron. 2010;65(6):886-98.

23. Lee J, et al. Ann Dermatol. 2016;28(2):159-63.

24. Kumagai H, et al. Nephrol Dial Transplant. 2010;25(4):1251-7.

25. Fishbane S, et al. Kidney Int Rep. 2020;5(5):600-10.

26. Fishbane S, et al. N Engl J Med. 2020;382(3):222-32.

27. Khanna R, et al. J Am Acad Dermatol. 2020;83(5):1529-33.

28. Mathur VS, et al. Am J Nephrol. 2017;46(6):450-8.

Poster PDF

Published

Jan 1, 2021

DOI https://doi.org/10.25251/skin.5.supp.31

How to Cite

[1]

Kim, B., Sciascia, T. and Yosipovitch, G. 2021. The Role of Kappa- and Mu-Opioid Receptors in Pruritus. SKIN The Journal of Cutaneous Medicine. 5, 1 (Jan. 2021), s31. DOI:https://doi.org/10.25251/skin.5.supp.31.

Issue

Vol. 5 No. 1 (2021): January Issue & Poster Presentations (WC21 Dermatology Conference®)

Section

Pruritus & Prurigo Nodularis

This work is licensed under a Creative Commons Attribution 4.0 International License.

All authors retain copyright in their articles. All articles published open access allowing for immediate free access to the work and permitting any user to read, download, copy, distribute, print, search, or link to the full texts of articles, crawl them for indexing, pass them as data to software or use them for any other lawful purpose. Permitted reuse is defined by the following user license:

Creative Commons Attribution (CC BY): lets others distribute and copy the article, to create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, even for commercial purposes, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, and do not modify the article in such a way as to damage the author's honor or reputation.

Authors retain copyright in their work and license the publisher to publish the content. The publisher is the National Society for Cutaneous Medicine, with production and publishing support provided by OJS, Open Journal Systems,see https://pkp.sfu.ca/ojs/.

Prior to January 2022, authors transferred copyright to the National Society for Cutaneous Medicine. However, all articles are freely available to anyone in the world. There are no subscription fees, page charges, or article processing charges.

Most read articles by the same author(s)

Brian Kim, Masato Tamari, Lydia Zamidar, Kristine Nograles, Catherine Munera, Joana Goncalves, Emma Guttman-Yassky, Mark Lebwohl, Oral Difelikefalin Reduces Pruritus in Atopic Dermatitis , SKIN The Journal of Cutaneous Medicine: Vol. 5 No. 6 (2021): November Issue & Poster Presentations (FC21 Dermatology Conference®)
Andrew Blauvelt, Jacek Szepietowski, Kim Papp, Eric Simpson, Jonathan Silverberg, Brian Kim, Shawn Kwatra, Michael Kuligowski, May Venturanza, Kang Sun, Leon Kircik, Itch-Free State in Patients With Atopic Dermatitis Treated With Ruxolitinib Cream , SKIN The Journal of Cutaneous Medicine: Vol. 5 No. 6 (2021): November Issue & Poster Presentations (FC21 Dermatology Conference®)
James Del Rosso, Gil Yosipovitch, Sonja Ständer, Jonathan Silverberg, Andreas Wollenberg, Peter A. Lio, Jose Manuel Carrascosa, Gaia Gallo, Marta Casillas, Evangeline Pierce, Yuxin Ding, Zhenhui Xu, Helena Agell, Linda Stein Gold, Lebrikizumab Provides Stable Itch Response With No or Minimal Fluctuations up to One Year in Patients With Atopic Dermatitis , SKIN The Journal of Cutaneous Medicine: Vol. 7 No. 6 (2023): November 2023 Issue
Elke Weisshaar, Thomas Sciascia, Sonja Stander, Efficacy and Safety of Oral Nalbuphine Extended Release in Prurigo Nodularis: Results of a Phase 2, Randomized, Controlled Trial with an Open Open-Label Extension Phase , SKIN The Journal of Cutaneous Medicine: Vol. 5 No. 1 (2021): January Issue & Poster Presentations (WC21 Dermatology Conference®)
Gil Yosipovitch, Claudia Zeidler, Christian J. Apfelbacher, Vivian Laquer, Brian S. Kim, Marta Casillas, Evangeline Pierce, Sherry Chen, Meihua Qiao, Helena Agell, James Del Rosso, Lebrikizumab Delivers Clinically Meaningful and Continuous Improvement in Itch-Free Days in Atopic Dermatitis Through One Year , SKIN The Journal of Cutaneous Medicine: Vol. 7 No. 6 (2023): November 2023 Issue
H. Chi-Ho Hong, Melinda Gooderham, Shawn Kwatra, Stamatios Gregoriou, Gil Yosipovitch, Pinaki Biswas, Andrew Selfridge, Christopher Koulias, Erman Güler, Efficacy of Abrocitinib and Dupilumab in Patients With Moderate-to-Severe Atopic Dermatitis With Severe Itch at Baseline and in Subgroups by Baseline Thresholds of Severe Itch: A Post Hoc Analysis of the JADE COMPARE and JADE DARE Clinical Trials , SKIN The Journal of Cutaneous Medicine: Vol. 8 No. 2 (2024): March 2024 Issue
Gil Yosipovitch, Eric Simpson, Andrew G Bushmakin, Joseph C Cappelleri, Thomas Luger, Sonja Stander, Wynnis Tom, Katy Benjamin, William C Ports, Anna M Tallman, Validation of the Severity of Pruritus Scale for the Assessment of Pruritus in Atopic Dermatitis , SKIN The Journal of Cutaneous Medicine: Vol. 1 (2017): Supplemental Issue: Scientific Posters Presented at 2017 Fall Clinical Dermatology Conference®-Las Vegas
Gil Yosipovitch, Eric Simpson, Huaming Tan, Robert A Gerber, Thomas Luger, Sonja Stander, Wynnis Tom, Joseph C Cappelleri, Andrew G Bushmakin, William C Ports, Anna M Tallman, The Effect of Crisaborole Ointment, 2%, on Pruritus in Patients with Atopic Dermatitis: An Extended Analysis , SKIN The Journal of Cutaneous Medicine: Vol. 1 (2017): Supplemental Issue: Scientific Posters Presented at 2017 Fall Clinical Dermatology Conference®-Las Vegas
Eric Simpson, Gil Yosipovitch, Kilian Eyerich, Delphine Staumont-Sallé, Mona Shahriari, Gaia Gallo, Eric Wolf, Evangeline Pierce, Chunyuan Liu, Jinglin Zhong, Helena Agell, Marjolein de Bruin-Weller, Lebrikizumab Provides Rapid Response in EASI Components and Itch in Moderate-to-Severe Atopic Dermatitis , SKIN The Journal of Cutaneous Medicine: Vol. 7 No. 6 (2023): November 2023 Issue
Sarina Elmariah, Sarah Chisolm, Thomas Sciascia, Shawn Kwatra, Modulation of the Mu and Kappa Opioid Axis for the Treatment of Chronic Pruritus , SKIN The Journal of Cutaneous Medicine: Vol. 5 No. 1 (2021): January Issue & Poster Presentations (WC21 Dermatology Conference®)

Main Article Content

Keywords

Abstract

References

Article Sidebar

Article Details

Similar Articles

Most read articles by the same author(s)