Vol. 5 No. 6 (2021): November Issue & Poster Presentations (FC21 Dermatology Conference®)

Jerry Bagel, Yipeng Wang, Paul Montgomery, III, Christian Abaya, Eric Andrade, Courtney Boyce, Tatiana Tomich, Byung-In Lee, David Pariser, Alan Menter, Tobin Dickerson

Page 621-638

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Disparities in Access to Teledermatology During the COVID-19 Pandemic in Detroit, Michigan

Angela Jiang, Reem Kashlan, Christine Joseph, Amy Tang, Henry Lim

Page 639-648

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Willingness of Patients from an Urban Safety-Net Dermatology Clinic to Receive a COVID-19 Vaccine

Hannah Mumber, Daniela Del Campo, Manuel Alvarado, Jacqueline Watchmaker

Page 649-655

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Research Letters

Virtual medical student dermatologic surgery workshop increases confidence in suturing and skin biopsy skills in the era of COVID-19

Emily Dando, MD, Angela Guerrero, MD, Mary-Katharine Collins, Alaina J. James

Page 656-659

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COVID Concepts

Pemphigus Foliaceous after COVID-19 Infection and Bamlanivimab Infusion

Katelyn Urban, Rachel L. Giesey, Gregory R. Delost

Page 660-663

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Brief Articles

Rare Mucosal Lip Atypical Fibroxanthoma Treated with Mohs Micrographic Surgery

Tara Howard, Taraneh Matin, John Howard, Eduardo Weiss Howard

Page 664-666

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Rapid Efficacy of Ixekizumab for Pediatric Acute Generalized Pustular Psoriasis

Linda Serrano, Valerie Carlberg, Kristen Holland

Page 667-671

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Diffuse Large B-cell Lymphoma in Bilateral Lower Extremities

Leon Kou, Kevyn Niu, Austin Wong, Aaron Chen, Sid Danesh

Page 672-675

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Atypical Targetoid Lesions as the Presenting Sign of Myeloid Sarcoma

Eduardo Adrian Rodriguez, Edward Visnaw, Frank Petr, Huma Siddiqui

Page 676-679

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A Cross-Sectional Survey of Students and Instructors on Virtual Dermatology Teaching in a Competency-based Format

Shara Chopra, Ankita Sinharoy, Alexandra Flamm

Page 680-684

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Multinucleate Cell Angiohistiocytoma: A Case Report and Unique Treatment Consideration

Maria Karim , Marlyn Wu, Adriana Ros

Page 685-688

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Dermatofibrosarcoma Protuberans Presenting as a Subcutaneous Cystic Nodule

Chris Logas, Austin Dunn, Danielle Lazarra, Justin Rubin, Eli Saleeby, Brad Glick

Page 689-692

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Successful Use of Apremilast in Psoriasiform Dermatitis Refractory to Biologics

Christopher Yang, Victor Quan, Ahmad Amin

Page 693-696

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Primary Cutaneous Plasmacytoma Treated with Palliative Radiotherapy: A Case Report and Literature Review

Suzanne Alkul, Yuangao Liu , Scott Whipple, Gordana Verstovsek, Soo Jung Kim

Page 697-701

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Short Communications

A Thousand Words for a Picture of Health

Amy Blake

Page 702-703

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Compelling Comments

Social Media and Skin Cancer Prevention: A Promising Platform for Education Among Adolescents and Young Adults

Mary Cavanagh, Brinda Chellappan

Page 704-705

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Poster Presentations from FC21 Dermatology Conference®: Psoriasis

A Phase 3, Randomized, Double-Blind, Vehicle-Controlled, Multicenter, Parallel Group Trial Investigating the Efficacy and Safety of Clobetasol Propionate Cream, 0.025% in the Treatment of Moderate to Severe Plaque Psoriasis for 14 Days

Seemal Desai, Zoe Draelos, Steve Feldman, J. Mark Jackson

Page s33

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Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Efficacy by Baseline Disease Characteristics and Demographics in Two Pivotal Phase 3 Trials

Leon Kircik, Linda Stein Gold, James Del Rosso, Seemal Desai, Brad Glick, Howard Sofen, Anna Tallman, David Rubenstein, Philip Brown

Page s34

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Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Long-Term Extension Trial of a Novel Therapeutic Aryl Hydrocarbon Receptor Modulating Agent

Bruce Strober , Linda Stein Gold, Robert Bissonnette, April Armstrong , Andrew Blauvelt, Philip Brown, Leon Kircik, Anna Tallman, Mark Lebwohl

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Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Versus Placebo and Apremilast in Moderate to Severe Plaque Psoriasis: Efficacy Analysis by Baseline Disease Characteristics From the Phase 3 POETYK PSO-1 and PSO-2 Trials

Joe Merola, Howard Sofen, Diamant Thaci, Carle Paul, Shinichi Imafuku, Subhashis Banerjee, April Armstrong

Page s36

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Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Compared With Placebo and Apremilast in Moderate to Severe Psoriasis: Integrated Laboratory Parameter Results From the Phase 3 POETYK PSO-1 and POETYK PSO-2 Trials

Diamant Thaci, Kenneth Gordon , Melinda Gooderham, Bruce Strober , Neil Korman, Subhashis Banerjee, Subhashis Banerjee, Elizabeth Colston, Jonghyeon Kim, John Throup, Akimichi Morita

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Deucravacitinib Improves Psoriasis Symptoms and Signs Diary Domain Scores in Patients With Moderate to Severe Plaque Psoriasis: Results From the Phase 3 POETYK PSO-1 and POETYK PSO-2 Studies

April Armstrong , Bruce Strober , Kenneth Gordon , Joe Zhuo, Brandon Becker, Renata Kisa, John Throup, Jonghyeon Kim, Kim Papp

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Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Versus Placebo and Apremilast in Moderate to Severe Plaque Psoriasis: Onset of Action in the Phase 3 POETYK PSO-1 and POETYK PSO-2 Trials

Neil Korman, Kim Papp, Jerry Bagel, Peter Foley, Akimichi Morita, Subhashis Banerjee, Elizabeth Colston, Tao Wang, John Throup, Diamant Thaci

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A randomized, investigator-blinded study to compare the efficacy and tolerance of a 650-microsecond, 1064-nm YAG laser to a 308-nm excimer laser for the treatment of mild-to-moderate psoriasis vulgaris

Mark Nestor, Daniel Fischer, David Arnold, Haowei Han, Anita Gade, Francesca Ceci, Austin Dunn, Alec Lawson

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Roflumilast Cream 0.3% Improved the Severity and Impact of Itch in Patients With Chronic Plaque Psoriasis in the Phase 3 DERMIS-1 and DERMIS-2 Studies

Javier Alonso-Llamazares, Melinda Gooderham, Jerry Bagel, John Browning, Zoe Draelos, Kimberly Grande, Adelaide Herbert, Wei Jing Loo, Chih-ho Hong, Mark Lebwohl, Walter Nahm, Kim Papp, David Pariser, Jennifer Soung, Linda Stein Gold, Irina Turchin, Amy Feng, Patrick Burnett, Robert Higham, David Berk

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Once-Daily Roflumilast Cream 0.3%, a Potent Phosphodiesterase-4 Inhibitor, Provided Safe and Effective Treatment of Psoriasis in the DERMIS-1 and DERMIS-2 Phase 3 Trials

Mark Lebwohl, Leon Kircik, Angela Moore, Linda Stein Gold, James Del Rosso, Zoe Draelos, Melinda Gooderham, Lawrence Green, Adelaide Herbert, Kim Papp, Jerry Bagel, Neal Bhatia, Laura Ferris, Terry Jones, Steve Kempers, David Pariser, Paul Yamauchi, Matthew Zirwas, Amy Feng, Patrick Burnett, Robert Higham, David Berk

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Once-Daily Roflumilast Foam 0.3% Improves Severity and Burden of Itch in Patients With Scalp and Body Psoriasis in a Randomized, Double-blind, Vehicle-Controlled Phase 2b Study

Angela Moore, Javier Alonso-Llamazares, Neal Bhatia, Alim Devani, Michael Bukhalo, Zoe Draelos, Melinda Gooderham, Steve Kempers, Leon Kircik, Kim Papp, David Pariser, Marina Sankeva, Rodney Sinclair, Matthew Zirwas, Amy Feng, Patrick Burnett, Robert Higham, David Berk

Page s43

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Long-term Safety and Efficacy of Roflumilast Cream 0.3% in Adult Patients With Chronic Plaque Psoriasis: Results From a 52-Week, Phase 2b Open-Label Study

Linda Stein Gold, Melinda Gooderham, Kim Papp, Laura Ferris, Mark Lebwohl, David Adam, Javier Alonso-Llamazares, Chih-ho Hong, Steve Kempers, Leon Kircik, Wei Jing Loo, Daniel Stewart, Walter Nahm, Matthew Zirwas, Patrick Burnett, Robert Higham, Lynn Navale, David Berk

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A Dermal Biomarker Patch Displays Excellent Analytical Performance and Outperforms Tape Stripping in Psoriatic Skin

Tobin Dickerson, Stephen Boyd, Eric Andrade, Christian Abaya, Yipeng Wang, Byung-In Lee

Page s45

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Mind.Px – Personalized Medicine for Psoriasis Biologic Treatment

Tobin Dickerson, Byung-In Lee, Paul Montgomery, Stephen Boyd, Eric Andrade, Courtney Boyce, Tatiana Tomich, Yipeng Wang

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Phase IV Evaluation of the Adrenal Suppression Potential and PKPD of Halobetasol Propionate Foam, 0.05% in Adolescent Subjects with Plaque Psoriasis

Adelaide Herbert, Rhonda Schreiber, Debbie Glaab, Lawrence Eichenfeld

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Long-term Safety and Efficacy of Fixed-Combination Halobetasol Propionate and Tazarotene Lotion in Patients With Clinically Meaningful Improvement in Plaque Psoriasis

Andrew Alexis, James Del Rosso, Tina Bhutani, Kim Papp, Abby Jacobson

Page s48

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Long-term Outcomes of Fixed-Combination Halobetasol Propionate and Tazarotene Lotion Stratified by Baseline Signs and Symptoms of Psoriasis

Leon Kircik, Lawrence Green, Joshua Zeichner, Javier Alonso-Llamazares, Abby Jacobson

Page s49

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Retreatment With Brodalumab Results in Skin Clearance and Improvements in Quality of Life in Patients With Psoriasis After Treatment Interruption

April Armstrong , Brian Keegan, George Han, Abby Jacobson

Page s50

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Efficacy of Brodalumab vs Ustekinumab by Prior TNFα Inhibitor Exposure: Post hoc Analysis of Two Phase 3 Psoriasis Studies

Alan Menter, Erin Boh, George Lewitt, Abby Jacobson

Page s51

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Bimekizumab response maintenance through two years of treatment in patients with moderate to severe plaque psoriasis who responded after 16 weeks: Interim results from the BE BRIGHT open-label extension trial

Bruce Strober , Akihiko Asahina, Ulrich Mrowietz, Mark Lebwohl, Peter Foley, Richard Langley, Jonathan Barker, Christopher Cioffi, Nancy Cross, Maggie Wang, Carle Paul

Page s52

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Bimekizumab versus secukinumab efficacy across subgroups of patients with moderate to severe plaque psoriasis: Results from the multicenter, randomized, double-blinded phase 3b BE RADIANT trial

Andrew Blauvelt, Lars Iversen, Sandy McBride, Melinda Gooderham, Petra Staubach, Paul Yamauchi, Fabienne Staelens, Veerle Vanoorden, Katy White, Paolo Gisondi

Page s53

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Number Needed to Treat Among Therapies for Patients with Moderate to Severe Plaque Psoriasis: Clinical Perspective of Results from a Network Meta-Analysis

C Leonardi, K Fahrbach, B Neupane, A Armstrong , K Gordon, S Kiri, V Taieb, L McClung

Page s54

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Mean percent PASI improvement with bimekizumab in patients with moderate to severe plaque psoriasis: Pooled results from four phase 3/3b trials

Andrew Blauvelt, George Han, Steve Tyring, Jennifer Soung, Tae Oh, Leah Davis, Veerle Vanoorden, Mark Lebwohl

Page s55

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Atopic Dermatitis

Neutralizing interleukin-13 increases skin microbial diversity: results from a Phase 3, randomized, double-blind, placebo-controlled trial of tralokinumab in adult patients with atopic dermatitis

Thomas Bieber, Lisa Beck, Andrew Pink, Hidehisa Saeki, Lawrence Eichenfeld, Thomas Werfel, Anders Rosholm, Mads Ropke, Amy Paller

Page s56

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Assessing long-term maintenance of efficacy with tralokinumab monotherapy in patients with moderate-to-severe atopic dermatitis: combined results from two phase 3, randomized, double-blind, placebo-controlled trials (ECZTRA 1 and 2)

Andrew Blauvelt, Anderas Wollenberg, Andrew Pink, Ketty Peris, April Armstrong , Lynda Spelman, Hidehisa Saeki, Charles Lynde, Pedro Herranz, Sebastien Barbarot, Eric Simpson

Page s57

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COVID-19 in tralokinumab-treated patients with moderate-to- severe atopic dermatitis: case series from the ECZTEND long- term extension trial

Andrew Blauvelt, Andrew Pink, Margitta Worm, Richard Langley, Antonio Costanzo, Le Gjerum, Emilie Jorgensen, Joshua Corriveau, Emma Guttman-Yassky

Page s58

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Long-Term Improvements Observed in Tralokinumab-Treated Patients with Moderate-to-Severe Atopic Dermatitis: an ECZTEND Interim Analysis

Andrew Blauvelt, Jean-Philippe Lacour, Darryl Toth, Vivian Laquer, Stefan Beissert, Andreas Wollenberg, Pedro Herranz, Andrew Pink, Ketty Peris, Stine Fangel, Hidehisa Saeki

Page s59

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Efficacy and safety of tralokinumab plus topical corticosteroids in patients with severe atopic dermatitis and prior history of dupilumab treatment: a post hoc subgroup analysis from ECZTRA 7 trial

Jan Gutermuth, Andrew Pink, Margitta Worm, Lise Soldbro, Thomas Mark, Joshua Corriveau, Christian Bjeeregard Oland, Stephan Weidinger

Page s60

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Rapid and sustained improvements in itch and sleep with tralokinumab treatment in patients with moderate-to-severe Atopic Dermatitis, a post hoc analysis of pooled data from ECZTRA 1 and 2

Eric Simpson, Anderas Wollenberg, Weily Soong, Thomas Mark, Alexandra Kuznetsova, Louise Abildgaard Steffensen, Jonathan Silverberg

Page s61

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Tapinarof Cream 1% Once Daily for the Treatment of Moderate to Severe Atopic Dermatitis in Children and Adults: The Pivotal Phase 3 ADORING Clinical Program

Lawrence Eichenfeld, Jonathan Silverberg, Robert Bissonnette, Anna Tallman, David Rubenstein, Stephen Piscitelli, John Jett

Page s62

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Long-Term Safety and Disease Control With Ruxolitinib Cream in Atopic Dermatitis: Results From Two Phase 3 Studies

Kim Papp, Jacek Szepietowski, Leon Kircik, Darryl Toth, Lawrence Eichenfeld, Seth Forman, Michael Kuligowski, May Venturanza, Kang Sun, Eric Simpson

Page s63

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Itch-Free State in Patients With Atopic Dermatitis Treated With Ruxolitinib Cream

Andrew Blauvelt, Jacek Szepietowski, Kim Papp, Eric Simpson, Jonathan Silverberg, Brian Kim, Shawn Kwatra, Michael Kuligowski, May Venturanza, Kang Sun, Leon Kircik

Page s64

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Long-term safety and disease control with ruxolitinib cream among patients with atopic dermatitis based on previous medication history: Pooled results from two phase 3 studies

Andrew Blauvelt, Lawrence Eichenfeld, Michael Kuligowski, May Venturanza, Kang Sun, Jonathan Silverberg

Page s65

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Long-Term Safety and Disease Control With Ruxolitinib Cream in Patients With More Severe Atopic Dermatitis: Pooled Results From Two Phase 3 Studies

Eric Simpson, Leon Kircik, Andrew Blauvelt, Michael Kuligowski, May Venturanza, Kang Sun, Lawrence Eichenfeld

Page s66

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Effects of Ruxolitinib Cream in Patients With Atopic Dermatitis With Head and/or Neck Involvement

Eric Simpson, Robert Bissonnette, Michael Kuligowski, May Venturanza, Kang Sun, Jonathan Silverberg

Page s67

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Acne & Rosacea

A Clinical Evaluation of the 1064nm Nd:YAG Laser with a 650-microsecond Pulse Duration for the Treatment of Acne Vulgaris

Tanya Greywal, Nazanin Saedi, Arisa Ortiz

Page s68

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Tazarotene 0.045% Lotion for Acne: Formulation, Application Characteristics, and Clinical Efficacy and Safety

Zoe Draelos, Emil Tanghetti, Linda Stein Gold, Hilary Baldwin, Leon Kircik, Eric Guenin

Page s69

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Efficacy and Safety of Tazarotene 0.045% Lotion in White Adults with Moderate-to-Severe Acne

James Del Rosso, Linda Stein Gold, Stephen Tyring, William Philip Werschler, Fran Cook-Bolden, George Han, Neal Bhatia, Eric Guenin

Page s70

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Improvements in Acne and Skin Oiliness with Tazarotene 0.045% Lotion in Acne Patients with Oily Skin

Emil Tanghetti, Michael Gold, Neil Sadick, Fran Cook-Bolden, Leon Kircik, Linda Stein Gold, Stephen Tyring, James Del Rosso, Eric Guenin

Page s71

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Oral Sarecycline for Treatment of Papulopustular Rosacea: Results of a Pilot Study Evaluating Efficacy and Safety

James Del Rosso, Leon Kircik, Cheryl Effron, Zoe Draelos

Page s72

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Sarecycline: Rapid Improvement of Truncal Acne in Hispanic Male

Angela Moore, Stephen Moore, Luke Moore, Stephen Tyring, Stephen Tyring

Page s73

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Hyperhidrosis

Investigating Treatment of Primary Axillary Hyperhidrosis With a Topical Retrometabolic Anticholinergic Drug

Nicholas Bodor, Adam Friedman, Stacy Smith, James Del Rosso, Janet Dubois, Adelaide Herbert, Tory Sullivan, Zakiya Rice, Joe Gorlick, Leon Kircik, Lawrence Green, Brandon Kirsch, Deepak Chadha

Page s74

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Pruritus & Prurigo Nodularis

Long-term Safety and Efficacy of Difelikefalin in Subjects With Chronic Kidney Disease–Associated Pruritus: Analysis From KALM-1 and KALM-2

Steve Fishbane, Warren Wen, Catherine Munera, Frédérique Menzaghi, Kieran McCafferty

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Oral Difelikefalin Reduces Pruritus in Atopic Dermatitis

Brian Kim, Masato Tamari, Lydia Zamidar, Kristine Nograles, Catherine Munera, Joana Goncalves, Emma Guttman-Yassky, Mark Lebwohl

Page s76

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Efficacy of Difelikefalin in Subjects With Moderate-to-Severe Chronic Kidney Disease–Associated Pruritus: Pooled Subgroup Analysis of KALM-1 and KALM-2

Joel Topf, Warren Wen, Catherine Munera, Frédérique Menzaghi, Michael Schömig

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Skin Cancer

The Cataylst Initiative: Innovative CME on Appropriate Use of Immunotherapy in the Systemic Treatment of Locally Advanced and Metastatic BCC and cSCC

Med Learning Group

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A comprehensive diagnostic offering workflow increases the rate of actionable results of the 23- and 35-gene expression profile tests for use as ancillary diagnostic tools for difficult-to-diagnose melanocytic lesions

Matthew Goldberg, Jennifer Siegel, Brooke Russell, Jason Rogers, Kyle Covington, Kristen Oelschlanger, Trisha Poteet, Jeffrey Wilkinson , Michael Berg, Katherine Falkowski, Sarah Kurley, Armineh Kajoian

Page s79

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Integrating the 31-gene expression profile and clinicopathologic data to determine the risk of sentinel lymph node positivity and recurrence-free survival in cutaneous melanoma

Brian Martin, Nicholas Taylor, Eric Whitman, Ann Quick, Christine Bailey, Kyle Covington, John Vetto

Page s80

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Field Treatments for Actinic Keratosis: A Systematic Review and Network Meta-Analysis

G Martin, B Berman, S Feldman, A Armstrong , M Edwards, S Graziadio, R McCool, M Arber, E Carr, D James, M Chapman-Rounds, E Fumero, M Schuchardt, A Grada

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Determination of the Area of Skin Capable of Being Covered by the Application of 250 mg of Tirbanibulin Ointment, 1%

Austin Dunn, Haowei Han, Anita Gade, Brian Berman

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Dermatopharmacology

Sarecycline exhibits decreased activity Against Representative Bacterial and Fungal Microflora Commonly Present in the Human Gastrointestinal Tract

Mahmoud Ghannoum, Janet Herrada, Ahmed Gamal, Lisa Long, Thomas McCormick, Ayman Grada

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Enhanced Uptake of 2% Salicylic Acid Following 1440-nm Non-ablative Fractional Diode Laser Treatment

Jordan Wang, Paul Friedman, Adarsh Konda, Catherine Parker, Roy Geronemus

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Enhanced Uptake of 10% Ascorbic Acid After 1440-nm or 1927-nm Non-ablative Fractional Diode Laser Treatment

Jordan Wang, Paul Friedman, Adarsh Konda, Catherine Parker, Roy Geronemus

Page S85

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Quantifying Uptake of Topical 4% Hydroquinone After 1440-nm and 1927-nm Non-ablative Fractional Diode Laser Treatment

Jordan Wang, Paul Friedman, Adarsh Konda, Catherine Parker, Roy Geronemus

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Quantifying Uptake of Eye Serum After 1440-nm or 1927-nm Non-ablative Fractional Diode Laser Treatment

Jordan Wang, Paul Friedman, Adarsh Konda, Catherine Parker, Roy Geronemus

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Disorders of Pigmentation

Cysteamine: Clinical efficacy, safety and tolerability versus best-in-class treatments for melasma

Seemal Desai

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Stabilized Cysteamine 5% Cream for the Treatment of Senile Lentigo

Nasrin Saki

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Miscellaneous

Long-Term Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Perimenopausal, Menopausal and Postmenopausal Women with Self-Perceived Thinning Hair

Glynis Ablon, Sheryl Berkowitz, Sophia Kogan, Isabelle Raymond

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Pooled Results of VP-102 Safety and Efficacy in Phase 3 Trials for Molluscum Contagiosum by Fitzpatrick Skin Type (FST)

Elaine Siegfried, Lawrence Eichenfeld, Pearl Kwong, Seemal Desai, Susan Cutler, Cynthia Wilson, Pamela Rumney, Christine Crosby, Jennifer Andres, Mark McBride

Page s91

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Proportion of Subjects Achieving a Molluscum Lesion Count of 0 or 1 at the Day 84 End of Study Visit in Phase 3 Clinical Trials with VP-102 CAMP-1 and CAMP-2

Lawrence Eichenfeld, Elaine Siegfried, Pearl Kwong, Susan Cutler, Cynthia Willson, Pamela Rumney, Christine Crosby, Jennifer Andres, Mark McBride

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Therapeutic Recommendations for the Treatment of Toenail Onychomycosis in the US

Shari Lipner, Warren Josepth, Tracy Vlahovic, Richard Scher, Phoebe Rich, Mahmoud Ghannoum, Ralph Daniel, Boni Elewski

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A Randomized, Double-blind, Vehicle-Controlled Phase 2a Study Evaluating Once Daily Roflumilast Foam 0.3% in Patients With Moderate to Severe Seborrheic Dermatitis

Matthew Zirwas, Zoe Draelos, Janet Dubois, Leon Kircik, Angela Moore, Linda Stein Gold, Javier Alonso-Llamazares, Michael Bukhalo, Suzanne Bruce, Kimmie Eads, Lawrence Green, Scott Guenthner, Laura Ferris, Seth Forman, Steven Kempers, Edward Lain, Charles Lynde, David Pariser, David Pariser, Darryl Toth, paul Yamauchi, Patrick Burnett, David Berk

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