Medium-Sized Congenital Melanocytic Nevus with Halo Phenomenon: A Report of Two Cases
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Keywords
Halo congenital melanocytic nevi, congenital melanocytic nevi, halo nevi, depigmented nevi, medium-sized congenital melanocytic nevi
Abstract
Congenital melanocytic nevi with halo phenomenon in children is a rare clinical finding. We report two cases of children who developed depigmentation within medium-size congenital melanocytic nevi. Clinicians should be suspicious when confronted with this phenomenon due to the risk of development into malignant melanoma. Herein, we review these rare cases of medium-sized halo congenital melanocytic nevi with and without associated vitiligo, with emphasis that depigmentation does not necessarily indicate malignant growth.
References
2. Haynes D, Strunck JL, Said J, et al. Association between halo nevi and melanoma in adults: A multicenter retrospective case series [published online ahead of print, 2020 Aug 18]. J Am Acad Dermatol. 2020;S0190-9622(20)32449-X. doi:10.1016/j.jaad.2020.08.056
3. Itin PH, Lautenschlager S. Acquired Leukoderma in Congenital Pigmented Nevus Associated with Vitiligo-Like Depigmentation. Pediatr Dermatol. 2002;19(1):73-75. doi:10.1046/j.1525-1470.2002.00028.x
4. Cusack C, Warde D, Lynch W, McDermott M, Watson R. Dramatic spontaneous regression of a medium-sized congenital melanocytic naevus. Clin Exp Dermatol. 2009;34(5):e34-e36. doi:10.1111/j.1365-2230.2008.03131.x
5. Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol. 1997;37(4):620-624. doi:10.1016/S0190-9622(97)70181-6
6. Yang Y, Li S, Zhu G, et al. A similar local immune and oxidative stress phenotype in vitiligo and halo nevus. J Dermatol Sci. 2017;87(1):50-59. doi:10.1016/j.jdermsci.2017.03.008
7. Das PK, van den Wijngaard RMJGJ, Wankowicz-Kalinska A, Le Poole IC. A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo. Trends Immunol. 2001;22(3):130-136. doi:10.1016/S1471-4906(00)01844-5
8. Barona MI, Arrunátegui A, Falabella R, Alzate A. An epidemiologic case-control study in a population with vitiligo. J Am Acad Dermatol. 1995;33(4):621-625. doi:10.1016/0190-9622(95)91282-7
9. Taïeb A, Picardo M. Vitiligo. N Engl J Med. 2009;360(2):160-169. doi:10.1056/NEJMcp0804388
10. Nath AK, Thappa DM, Rajesh NG. Spontaneous regression of a congenital melanocytic nevus. Indian J Dermatol Venereol Leprol. 2011;77(4):507. doi:10.4103/0378-6323.82418
11. Kim HS, Goh BK. Vitiligo Occurring after Halo Formation around Congenital Melanocytic Nevi. Pediatr Dermatol. 2009;26(6):755-756. doi:https://doi.org/10.1111/j.1525-1470.2009.01030.x
12. Weyant GW, Chung CG, Helm KF. Halo nevus: review of the literature and clinicopathologic findings. Int J Dermatol. 2015;54(10):e433-435. doi:10.1111/ijd.12843