Three Year Anniversary of the Introduction of Deucravacitinib to the US Market
Main Article Content
Keywords
Deucravacitinib, Janus kinase inhibitor, psoriasis, lupus
References
1. Burke JR, Cheng L, Gillooly KM, et al. Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain. Sci Transl Med. 2019;11(502):eaaw1736. doi:10.1126/scitranslmed.aaw1736
2. Armstrong AW, Lebwohl M, Warren RB, et al. Deucravacitinib in plaque psoriasis: Four-year safety and efficacy results from the Phase 3 POETYK PSO-1, PSO-2 and long-term extension trials. J Eur Acad Dermatol Venereol. 2025;39(7):1336-1351. doi:10.1111/jdv.20553
3. Mima Y, Yamamoto M, Iozumi K. Deucravacitinib Treatment for Psoriasis Complicated by Myelodysplastic Syndrome Without Exacerbation of the Underlying Hematologic Disorder: A Case Report. Cureus. 2025;17(5):e84075. Published 2025 May 14. doi:10.7759/cureus.84075
4. Armstrong AW, Kircik L, Stein Gold L, et al. Deucravacitinib: Laboratory Parameters Across Phase 3 Plaque Psoriasis Trials. Dermatol Ther (Heidelb). 2025;15(4):1025-1035. doi:10.1007/s13555-025-01362-w
5. HIGHLIGHTS of PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/214958s000lbl.pdf
6. Armstrong AW, Gooderham M, Warren RB, et al. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial. J Am Acad Dermatol. 2023;88(1):29-39. doi:10.1016/j.jaad.2022.07.002
7. Lebwohl M, Bukhalo M, Stein Gold L, et al. A randomized phase 3b study evaluating the safety and efficacy of risankizumab in adult patients with moderate-to-severe plaque psoriasis with non-pustular palmoplantar involvement. J Am Acad Dermatol. 2024;91(6):1150-1157. doi:10.1016/j.jaad.2024.07.1521
8. Hagino T, Onda M, Saeki H, Fujimoto E, Kanda N. Effectiveness of deucravacitinib for genital, nail and scalp lesions in patients with psoriasis: a 24-week real-world study. Clin Exp Dermatol. 2024;50(1):130-133. doi:10.1093/ced/llae312
9. Guénin S, Andrews E, Lebwohl MG. Safety and efficacy of dual tyrosine kinase 2 inhibitor and monoclonal antibody therapy for psoriasis and psoriatic arthritis. Br J Dermatol. 2024;190(3):451-453. doi:10.1093/bjd/ljad473
10. Mease PJ, Deodhar AA, van der Heijde D, et al. Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthritis. Ann Rheum Dis. 2022;81(6):815-822. doi:10.1136/annrheumdis-2021-221664
11. Morand E, Pike M, Merrill JT, et al. Deucravacitinib, a Tyrosine Kinase 2 Inhibitor, in Systemic Lupus Erythematosus: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Rheumatol. 2023;75(2):242-252. doi:10.1002/art.42391
12. Bokor LA, Martyin K, Krebs M, et al. Deucravacitinib shows superior efficacy and safety in cutaneous lupus erythematosus compared to various biologics and small molecules - A systematic review and meta-analysis. Autoimmun Rev. 2025;24(3):103723. doi:10.1016/j.autrev.2024.103723
13. Matthew EJ, Verma KK, Paulger B. Oral Deucravacitinib for Treatment-Refractory Cutaneous Lupus Erythematosus. Cureus. 2025;17(3):e81539. Published 2025 Mar 31. doi:10.7759/cureus.81539
14. Ezeh N, Vleugels RA, Shahriari N. Discoid lupus erythematosus successfully treated with deucravacitinib. JAAD Case Rep. 2024;49:59-61. Published 2024 Apr 30. doi:10.1016/j.jdcr.2024.04.032
15. Bouché N, Al-Saedy MA, Song EJ. Successful treatment of refractory subacute cutaneous lupus erythematosus with deucravacitinib. JAAD Case Rep. 2023;39:93-95. Published 2023 Aug 4. doi:10.1016/j.jdcr.2023.07.030
16. Assaf K, Patt S, Schäfer VS, Wenzel J, Novak N, Wilsmann-Theis D. Successful treatment of subacute cutaneous lupus erythematosus with the TYK-2 inhibitor deucravacitinib in a patient with concomitant psoriasis vulgaris. J Dtsch Dermatol Ges. 2025;23(7):874-877. doi:10.1111/ddg.15705
17. Aw K, Gavigan G. Treatment of discoid lupus erythematosus scarring alopecia with deucravacitinib: A case report. SAGE Open Med Case Rep. 2025;13:2050313X241304891. Published 2025 Jan 2. doi:10.1177/2050313X241304891
18. Kurz B, Ivanova I, Drexler K, Berneburg M, Günther F, Niebel D. Rapid clinical improvement of refractory subacute cutaneous lupus erythematosus with oral tyrosine kinase 2 inhibitor deucravacitinib: A case report. J Eur Acad Dermatol Venereol. 2024;38(5):e434-e436. doi:10.1111/jdv.19667
2. Armstrong AW, Lebwohl M, Warren RB, et al. Deucravacitinib in plaque psoriasis: Four-year safety and efficacy results from the Phase 3 POETYK PSO-1, PSO-2 and long-term extension trials. J Eur Acad Dermatol Venereol. 2025;39(7):1336-1351. doi:10.1111/jdv.20553
3. Mima Y, Yamamoto M, Iozumi K. Deucravacitinib Treatment for Psoriasis Complicated by Myelodysplastic Syndrome Without Exacerbation of the Underlying Hematologic Disorder: A Case Report. Cureus. 2025;17(5):e84075. Published 2025 May 14. doi:10.7759/cureus.84075
4. Armstrong AW, Kircik L, Stein Gold L, et al. Deucravacitinib: Laboratory Parameters Across Phase 3 Plaque Psoriasis Trials. Dermatol Ther (Heidelb). 2025;15(4):1025-1035. doi:10.1007/s13555-025-01362-w
5. HIGHLIGHTS of PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/214958s000lbl.pdf
6. Armstrong AW, Gooderham M, Warren RB, et al. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial. J Am Acad Dermatol. 2023;88(1):29-39. doi:10.1016/j.jaad.2022.07.002
7. Lebwohl M, Bukhalo M, Stein Gold L, et al. A randomized phase 3b study evaluating the safety and efficacy of risankizumab in adult patients with moderate-to-severe plaque psoriasis with non-pustular palmoplantar involvement. J Am Acad Dermatol. 2024;91(6):1150-1157. doi:10.1016/j.jaad.2024.07.1521
8. Hagino T, Onda M, Saeki H, Fujimoto E, Kanda N. Effectiveness of deucravacitinib for genital, nail and scalp lesions in patients with psoriasis: a 24-week real-world study. Clin Exp Dermatol. 2024;50(1):130-133. doi:10.1093/ced/llae312
9. Guénin S, Andrews E, Lebwohl MG. Safety and efficacy of dual tyrosine kinase 2 inhibitor and monoclonal antibody therapy for psoriasis and psoriatic arthritis. Br J Dermatol. 2024;190(3):451-453. doi:10.1093/bjd/ljad473
10. Mease PJ, Deodhar AA, van der Heijde D, et al. Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthritis. Ann Rheum Dis. 2022;81(6):815-822. doi:10.1136/annrheumdis-2021-221664
11. Morand E, Pike M, Merrill JT, et al. Deucravacitinib, a Tyrosine Kinase 2 Inhibitor, in Systemic Lupus Erythematosus: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Rheumatol. 2023;75(2):242-252. doi:10.1002/art.42391
12. Bokor LA, Martyin K, Krebs M, et al. Deucravacitinib shows superior efficacy and safety in cutaneous lupus erythematosus compared to various biologics and small molecules - A systematic review and meta-analysis. Autoimmun Rev. 2025;24(3):103723. doi:10.1016/j.autrev.2024.103723
13. Matthew EJ, Verma KK, Paulger B. Oral Deucravacitinib for Treatment-Refractory Cutaneous Lupus Erythematosus. Cureus. 2025;17(3):e81539. Published 2025 Mar 31. doi:10.7759/cureus.81539
14. Ezeh N, Vleugels RA, Shahriari N. Discoid lupus erythematosus successfully treated with deucravacitinib. JAAD Case Rep. 2024;49:59-61. Published 2024 Apr 30. doi:10.1016/j.jdcr.2024.04.032
15. Bouché N, Al-Saedy MA, Song EJ. Successful treatment of refractory subacute cutaneous lupus erythematosus with deucravacitinib. JAAD Case Rep. 2023;39:93-95. Published 2023 Aug 4. doi:10.1016/j.jdcr.2023.07.030
16. Assaf K, Patt S, Schäfer VS, Wenzel J, Novak N, Wilsmann-Theis D. Successful treatment of subacute cutaneous lupus erythematosus with the TYK-2 inhibitor deucravacitinib in a patient with concomitant psoriasis vulgaris. J Dtsch Dermatol Ges. 2025;23(7):874-877. doi:10.1111/ddg.15705
17. Aw K, Gavigan G. Treatment of discoid lupus erythematosus scarring alopecia with deucravacitinib: A case report. SAGE Open Med Case Rep. 2025;13:2050313X241304891. Published 2025 Jan 2. doi:10.1177/2050313X241304891
18. Kurz B, Ivanova I, Drexler K, Berneburg M, Günther F, Niebel D. Rapid clinical improvement of refractory subacute cutaneous lupus erythematosus with oral tyrosine kinase 2 inhibitor deucravacitinib: A case report. J Eur Acad Dermatol Venereol. 2024;38(5):e434-e436. doi:10.1111/jdv.19667
