Energy-Based Non-Light Devices for Dermatological Conditions: Current Indications and New Innovations
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Keywords
energy based devices, laser, Radiofrequency (RF), Ultrasound therapy, Cryolipolysis, Microwave therapy, Cold atmospheric plasma, Minimally invasive procedures
Abstract
Background Non–light-based energy devices are increasingly used in dermatology as minimally invasive treatments that employ thermal, mechanical, and electromagnetic energy for medical and aesthetic indications. This review summarizes current evidence and emerging innovations in this rapidly evolving field.
Methods A targeted PubMed search was performed using the keywords radiofrequency, microwave, ultrasound, energy-based devices, and dermatology. English-language articles were included, supplemented by citation tracking and authors’ clinical expertise.
Results Radiofrequency (RF) devices demonstrate efficacy for skin laxity, rhytides, acne, acne scarring, vascular lesions, hyperhidrosis, and select cutaneous neoplasms through thermally induced dermal remodeling. Fractional RF microneedling is particularly effective in darker skin phototypes with low risk of postinflammatory hyperpigmentation. High-frequency RF ablation provides precise, low-pain treatment of benign cutaneous lesions. Ultrasound therapies, including high-intensity focused ultrasound, are effective for skin tightening, body contouring, cellulite, inflammatory dermatoses, and selected keratinocyte carcinomas. Cryolipolysis achieves significant localized fat reduction with evidence of dermal remodeling. Microwave therapy is effective for actinic keratoses, viral warts, axillary hyperhidrosis, and osmidrosis. Cold atmospheric plasma shows promise for infectious, inflammatory, and neoplastic skin conditions.
Conclusion Non–light-based energy devices offer versatile, safe treatment options across dermatology with minimal downtime and applicability to all skin phototypes. Ongoing advances emphasize precision delivery, combination therapies, and personalized treatment strategies.
References
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3. Ravindran R, Pizzol D, Rahmati M, et al. Cryolipolysis and Associated Health Outcomes, Adverse Events, and Satisfaction: A Systematic Review and Meta-Analysis. Obesity Reviews. 2025;26(8):e13925.
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5. Zhai SY, Kong MG, Xia YM. Cold Atmospheric Plasma Ameliorates Skin Diseases Involving Reactive Oxygen/Nitrogen Species-Mediated Functions. Frontiers in Immunology. 2022;13:868386.
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