Wound Healing: Mechanisms, Advanced Management, and the Evolving Role of the Dermatologist
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Keywords
Wound healing, Chronic wounds, wound care, negative pressure wound therapy, allograft
Abstract
Cutaneous wound healing is a complex process, and dermatology offers a critical perspective given the pathophysiology of wounds. Chronic wounds, defined as wounds that persist without significant healing after four weeks of conservative management, such as diabetic foot ulcers, venous and arterial ulcers, pressure injuries, and non-healing surgical wounds, stall in normal healing stages, creating a pro-inflammatory and non-resolving microenvironment. Current management focuses on systemic optimization and local wound management, while emerging therapies like tissue-engineered substitutes, negative pressure therapy, hyperbaric oxygen, and cellular and acellular matrix-like products are gaining traction as treatment options. Dermatologists bring expertise in cutaneous pathophysiology that can enhance multidisciplinary models of care and improve clinical outcomes.
References
2. Dhillon Y, Levine L, Tovmassian G, et al. A Multicenter, Randomized, Controlled, Clinical Trial Evaluating a Lyopreserved Amniotic Membrane in the Treatment of Venous Leg Ulcers. Health Sci Rep. 2025;8(5):e70819. Published 2025 May 4. doi:10.1002/hsr2.70819
3. Holl J, Kowalewski C, Zimek Z, et al. Chronic Diabetic Wounds and Their Treatment with Skin Substitutes. Cells. 2021;10(3):655. doi:10.3390/cells10030655
4. Han G, Ceilley R. Chronic Wound Healing: A Review of Current Management and Treatments. Ado Ther. 2017;34(3):599-610. doi:10.1007/s12325-017-0478-y
5. Wu S, Carter M, Cole W, et al. Best practice for wound repair and regeneration use of cellular, acellular and matrix-like products (CAMPs). J Wound Care. 2023;32(Sup4b):S1-S31. doi:10.12968/jowc.2023.32.Sup4b.S1
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